Steven D. Fenster, Ph.D

Steven Fenster is an associate professor in the Department of Biology and Toxicology.  He is a graduate of the University of California at San Diego (1991) and earned his doctorate in Cell Biology from the University of Alabama at Birmingham (2000).  His dissertation research resulted in the discovery and characterization of a novel brain protein called Piccolo now shown to be critical for nervous system development.  As a post-doctoral research fellow in the Department of Developmental Neurobiology at St. Jude Children’s Hospital, he employed genetically engineered mice as models to study autism and pediatric brain cancer.  His research demonstrated the effective use of a commonly used anti-epileptic drug as a potential treatment for brain cancer.  In addition, he investigated the genetic basis of Rett Syndrome, a leading cause of autism in girls.  He currently studies a brain-specific protein called neuronal interleukin-16, a cytokine precursor molecule, that is believe to regulate neuronal cell signaling.  Prior to entering graduate school, he worked as a research technician at The Agouron Institute in La Jolla, California where he help to develop pre-clinical approaches targeted against HIV.  He has also served as adjunct professor at Birmingham-Southern College and spent a year as a visiting professor at The College of Wooster.  In his current position, he teaches Cell Biology, Genetics, Molecular Biology, Human Biology, and Introduction to Biotechnology.  He is also director of the Choose Ohio First Scholarship Program, a member of Faculty Senate, and a member of the College Symposium Committee and Professional Development Committee.

In his spare time, Dr. Fenster enjoys competing in running races, bicycling, and hiking.

Education:

University of Alabama-Birmingham  Cell Biology      Ph.D, 2000
University of California-San Diego  Biology B.S. 1991 

Appointments:
Associate Professor of Biology (as of July 2011)    Ashland University 2006-present
Visiting Assistant Professor The College of Wooster   2005-2006
Post-Doctoral Fellow   St. Jude Children’s Research Hospital   2003-2005
Research Associate   University of Alabama-Birmingham 2001-2003
Post-Doctoral Fellow   University of North Carolina-Chapel Hill   2000-2001
Adjunct Professor  Birmingham-Southern University  2000-2003

Publications:

Fenster .CP, Chisnell H.K, Fry C.R, Fenster S.D. 2010. The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons.  Neuroscience Letters.  485(3):212-216

Fraga D., Meulia T., Fenster S.D., Real-Time PCR. 2008. In Current Protocols Essential Laboratory Techniques, 2008, New Jersey:  John Wiley and Sons.


Fenster C.P, Fenster S.D., Leahy H.P, Kurschner, C. , Blundon J.A. 2007, Modulation of Kv4.2 K+ currents by neuronal interleukin-16, a PDZ domain-containing protein expressed in the hippocampus and cerebellum. Brain Research, 8; 19-31 (cover photo)

Ordway J.M.*, Fenster S.D.*, Ruan H. and Curran T. 2005. A transcriptome map of cellular transformation by the fos oncogene.  Molecular Cancer. 4:19.  *co-first author

Fenster, S.D., Kessels, M.M., Qualmann, B., Chung, W.J., Nash, J., Gundelfinger, E.D., and Garner, C.C. 2003. Interactions between Piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones. Journal of Biological Chemistry. 278:20268-20277

Fenster, S.D., Garner C.C., 2002. Gene structure and genetic localization of the PCLO gene encoding the presynaptic active zone protein Piccolo.  International Journal of Developmental Neuroscience. 20:3-5:161-171  
 
Fenster, S.D., Chung, W.J., Zhai, R., Cases-Langhoff, C., Voss, B., Garner, A.M., Kaempf, U., Kindler, S., Gundelfinger, E.D., and Garner, C.C. 2000. Piccolo, a presynaptic zinc finger protein structurally related to Bassoon. Neuron. 25:203-214

Muller, B.M., Kistner, U., Kindler, S., Chung, W.J., Kuhlendahl, S., Fenster, S.D., Lau, L.F., Veh, R.W., Huganir, R.L., Gundelfinger, E.D., and Garner, C.C. 1996. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron. 17:255-265

Fenster, S.D.,
Wagner, R.W., Froehler, B.C., and Chin, D.J. (1994). Inhibition of human immunodeficiency virus Type-1 Env expression by C-5 propyne oligonucleotides specific for rev-response element stem-loop V. Biochemistry, 33, 8391-8398.


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